![]() Normally, cyclic AMP binds to the regulatory subunit of protein kinase A, which allows the catalytic subunit to phosphorylate the transcription factor CREB (cyclic AMP–responsive element–binding protein), leading to synaptic strengthening and, eventually, to memory formation. Directly or indirectly, toxic Aβ species interfere with the production of cyclic AMP by adenylate cyclase. These fragments aggregate to form relatively soluble oligomers that are thought to damage synapses, perhaps by lodging in the membrane (as shown). The processing of amyloid precursor protein by presenilin and β-secretase generates fragments of the β-amyloid peptide (Aβ) in the neuron. A recent study by Gong et al., 1 however, suggests a new way of thinking about memory deficits in patients with Alzheimer's disease and hints at new therapeutic opportunities. Because of this, we have generated only a few ideas about how to prevent damage to the brain. ![]() ![]() Although we now know a lot about the biochemistry of the disease, there are some gaps in our knowledge about the links between small changes in molecules at the surface of neurons and the symptoms of disease. We often do not realize how much we need something until it is gone - and Alzheimer's disease shows us how debilitating it is to lose memory. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.
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